Zeposia®
Drug class
- Non-biologic small molecule
- Non-biologic small molecule - S1P receptor modulator
Generic name
Ozanimod
Safety
Efficacy
Convenience
Indications
Approved for treatment of moderate to severe active ulcerative colitis.
How it works
Targets and lessens the movement of white blood cells that cause inflammation.
Drug interactions
Avoid use of live attenuated vaccines during and for up to 3 months after treatment. Do not eat or drink foods and beverages with very high amounts of tyramine, such as some cheeses and red wine, which may cause sudden and severe high blood pressure.
Pre-treatment screening tests
Complete blood count, including lymphocyte counts, bilirubin and transaminase levels in all patients prior to therapy initiation, electrocardiogram (ECG), ophthalmologic exam, blood pressure.
Tests during screening
Complete blood count, including lymphocyte counts, bilirubin and transaminase levels, electrocardiogram (ECG), ophthalmologic exam and blood pressure. Monitor for and educate patient to report signs of infection, signs of liver dysfunction, signs of neuro dysfunction (behavioral changes, change in vision, weakness), or respiratory status changes.
Payment options
https://www.zeposia.com/ulcerative-colitis/copayRoute of administration
Frequency
1 time every day
Side effects
Upper respiratory infections (flu and colds), high liver enzymes, headache, fever, nausea or upset stomach, joint pain.
Contraindications
Myocardial infarction, unstable angina, stroke, transient ischemic attack, decompensated heart failure requiring hospitalization, or class III or IV heart failure in the last 6 months; Mobitz type II second- or third-degree atrioventricular block, sick sinus syndrome, or sinoatrial block, unless the patient has a functioning pacemaker; severe untreated sleep apnea; concomitant use of a monoamine oxidase inhibitor.
Safety information
Signs of a serious infection, fever, feeling tired, flu like symptoms, cough, painful and frequent urination, rash, headache with fever, neck stiffness, sensitivity to light or confusion, slow heart rate, change in eyesight.